Positive and negative cytomegalovirus igg, the consequences

Threat cytomegalovirus infection is a disease that belongs to a family of viruses herpes. Are the infection is spread everywhere in many civilized countries of the world. It is characterized not only by lifelong persistence of the virus, but also a periodic change of acute conditions and recurrences. CMV can be detected in the blood of specific antibodies of class IgG and IgM.

Incidence rates range from 40 to 60%. The detection rate of these seropositive results is determined by feedback from the social status of the person. Transmission of the infection occurs usually at sufficiently close contacts with the media. Infected the secret is in the saliva, semen, blood, cervical and vaginal secretions, and breast milk.

Cytomegalovirus often takes place completely asymptomatic. During primary infection during pregnancy there is a high risk of fetal infection. It should be noted that the disease, the frequency of intrauterine infection is in the first place. As a result of the cases of various pathologies of the development of the baby.

The consequences of intrauterine infection of the child can occur immediately after birth and be a major cause of birth defects. That is why it is so important mandatory diagnosis of each woman before conception.

As a rule, primary diagnosis of cytomegalovirus in acute form are detected specific antibodies to the infection IgG and IgM. Indicator of the acute form is the high number of them. Many of the antibodies indicates recent or reactivated disease. For accurate diagnosis is often a special analysis of the avidity of antibodies in the form of a kind of additional test.

Cytomegalovirus igg positive

In the case of a positive reaction for IgM antibody and low avidity index for IgG is talking about the primary infection. Moreover, the infection is in the human body not more than four months. To fully prove infection with this virus, the specialist will prescribe different blood tests and certain laboratory tests. Their main task is the proof of presence of antibodies inblood. For the detection of DNA of cytomegalovirus using another modern method of PCR.

For the implementation of developing CMV specific immune changes in the body. It is proved that the incubation period is from 15 days to 60 days, depending on the age and health of the person. Immunity in such infections is considered slow and unstable. It is also possible to reactivation of latent infection or exogenous reinfection, a typical virus. Due to the long persistence of such a dangerous virus in the body affects all the parts of the immune system of the patient.

Protective reaction of the organism is based primarily on the formation of specific antibodies against cytomegalovirus infection such classes IgM and IgG. These specific antibodies are responsible for the complete lysis of intracellular virus. Moreover, they inhibit intracellular replication. In the serum of each patient after the initial infection existing antibodies react with internal proteins. In problemsa patients serum contained only antibodies that react with glycoproteins of the envelope.

A certain amount of IgM is the main indicator of disease activity, which plays an important role in the diagnosis. This figure indicates the severity of the infection, reinfection or reactivation. The appearance of IgM antibodies in previously seronegative patient determines the primacy of the disease. IgM antibodies are formed irregularly, only when endogenous reactivation of cytomegalovirus. Usually they are in fairly low concentrations.

Detection of antibodies to allow a meaningful observation in the desired dynamics for patients with clinical manifestations of this disease, aiding in retrospective diagnosis. It should be noted that in severe forms of CMV production of antibodies may be very slow. This applies to expectant mothers, small children and people with lowered immunity.

The main indicator of avidity to cytomegalovirus infection characterizes the undoubted strength of the link is relevant antigens and specific antibodies. They represent the formation of the specific immune response of human body to negative the introduction of infection. The result is, by definition, IgM will help to make the clinical picture presented of the incidence of the virus.

The rate of cytomegalovirus igg

The rate of CMV igg is 0.5 lgM. If you have the tests showed a figure lower than this, then you have a negative test for CMV igg