Symptoms of liver necrosis

The liver, the largest unpaired organ maintains homeostasis of the organism, participates in the implementation of most of its metabolic processes. Liver function is diverse. The body plays an important role in metabolism, digestion, purification of blood from toxic substances from the gastrointestinal tract and enter the body from the environment.

Healthy liver copes with the reactions of the immunological system of oversight and primacy in the process of krovoobrashseniya. Poor diet and a number of other harmful factors, as well as inflammatory processes lead to the violation of its functions and the emergence of various pathologies, most clearly manifested in the development of liver failure and jaundice.

Necrosis or tissue death in a living organism is always evidence of severe, progressive course of pathological process. For necrosis of the liver characterized by the appearance of acute pain and dyspeptic syndromes. In most patients the disease can develop gradually and be very subtle in the early stages. Most frequently, the patients have icteric symptoms.

There has been an increasing weakness, lack of appetite, nausea accompanied by vomiting, diarrhea, dehydration and sudden loss of body weight. Pain arises in the right upper quadrant and epigastric region, possible febrile state. On palpation the liver, there is discomfort and pain, found enlargement of the spleen, there is erythema, vascular spiders in the skin, asterixis, confusion, agitation. The occurrence of ascites resistant to diureticum the symptom development of necrosis of the liver.

On the development of the pathology indicates a decrease in the flow of bile into the duodenum, while patients have skin itching. In the blood revealed the increase in bilirubin and increase in cholesterol. Along with this increased activity of alkaline phosphatase. If we consider the liver affected by necrosis under the microscope, you can see the changes of the cell nucleus and cytoplasm.

For hepatocytes characteristic of coagulation, colliquation necrosis and heart attacks. Coagulation necrosis observed in the liver cells when excess of protein. This necrosis may cover part or all of the cytoplasm. Colliquation necrosis occurs in hepatocytes the poor in protein and rich proteases. The cells increased in size, look empty, without a core.

On the severity and localization distinguish focal, zonal, there are centrolobular, submassive and massive necrosis. In the foci of necrosis observed in the development of reactive and reparative processes, meaning the migration of leukocytes out of the vessels, expressed mesenchymal proliferation of the cellular elements and small cluster of macrophages. In the treatment of different types of necrosis, it is first necessary to eliminate its causes.

It is also important to try to prevent its further spread and development. In the complex of therapeutic measures necessarily includes antibacterial, detoxication and desensitizing therapy. Effective impact on the improvement of the patient's condition provides the normalization of cardiac activity. The elimination of a vascular obstruction or restore the integrity of blood vessels leads to normal blood flow to the organ.

Attenuation of pathological processes depends on the elimination of compression and damage to the nerves, spinal cord, etc. Success is inevitable if you can encourage immunobiological powers and regenerative properties. Helps and symptomatic therapy. After identifying the boundaries of the demarcation line is carried out necrectomy (excision of dead tissue) within the viable tissue.

The diagnosis of necrosis of the liver is based on anamnesis, test results, histological confirmation using biopsy of the liver. Laboratory parameters do not allow to distinguish necrosis from any form of hepatitis. In the treatment required a complete rejection of alcohol consumption, meals should include proteins, vitamins, amino acids. We recommend a course of multivitamin therapy, treatment enzyme and metabolic medicine.

The attending physician depending on the situation assigned Heptral, Essentiale Forte, legalon, categen. In the case of manifestations of insufficient blood supply to the brain (encephalopathy), the use of glucocorticoids, it would be very appropriate. An adverse outcome of necrosis is accompanied by severe complications. Necrosis of vital organs often leads to death, but if patients survive, it develops scar connective tissue is formed postnecrotic cirrhosis of the liver. This is the forecast for the development of liver necrosis in case of late diagnosis.