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Diffuse changes of the liver parenchyma

The liver is the organ that not long declares itself in case of illness. Most often they are discovered during ultrasound diagnostics. And quite often, the extract is possible to meet a small but frightening record - diffuse changes of a parenchyma of a liver. Do not panic, we should first try to understand what this phrase means. As such, the diagnosis of "diffuse changes of a parenchyma of a liver" does not exist. The entry can only mean, that in the body there are certain processes that caused this condition. And that's what happened you need to determine with the help of research of different nature.

Diffuse changes may be a symptom of such diseases:

To understand what was going on, you should know that the parenchyma is not a shell, but a collection of the most important elements responsible for the operation of the authority. The liver is composed of parenchymal tissue, which, in turn, is formed from specific cells called hepatocytes.

So saying that the parenchyma has diffuse changes, the doctor involves the transformation of the liver tissue. So, minor deviations may be due to a viral disease. But there are severe lesions, so be sure to conduct additional research that will allow vivait the depth of the liver. But in any case, diffuse changes of the liver parenchyma cannot be ignored, and the identification of the causes that led to such state is the key to successful treatment.

The content of the article:


Signs of diffuse changes of the liver

With regard to the distinct characteristics with the defeat of the liver tissue, they show up pretty rarely.

But sometimes the seal is accompanied by a number of symptoms that a person feels:

  • After a meal, particularly roasted orsharp, appearance of the feeling of heaviness.
  • Bitter taste in the mouth, it is most pronounced in the morning after sleeping or after eating.
  • A feeling of weakness and fatigue, even after small exertion.
  • Nausea, it's not poisoning.

  • Irritability and frequent headaches, mood swings.

The most pronounced symptoms, especially with the progression of some diseases, leading to major changes in the parenchyma of the liver is pain in the right hypochondrium, yellowing of the sclera and even tongue are anxiety symptoms. It's the characteristics that you can notice and feel the person, and seek medical help.


Diagnostic methods

Main method allowing to assess the nature of diffuse changes of a parenchyma of a liver, and ultrasound. The signs by which a doctor determines them, can be both severe and moderate.

To some extent, the diagnosis allows to identify:

  • All serious diseases, previously transferred to, or occurring in a given time. They leave on the body traces, so the doctor will definitely see these telltale signs of decomposition of certain areas of the liver.
  • Mild signs usually do not cause such serious defeats, but ultrasound is noticeable and can be caused by viruses, malnutrition, etc.

On ultrasound the doctor determines the size of each lobe of the organ, its echogenicity and contour sharpness and uniformity of structure.

A qualified specialist will see by echo - signs of diffuse changes of the body, these include:

  • The heterogeneous tissue structure.
  • Parenchyma with increased echoprotocol.
  • The size of the body is increased.
  • The pattern of blood vessels is impaired.
  • In different hepatic lobes observed reduced and increased echogenicity.
  • Seal periportally paths.
  • The rapid attenuation of ultrasound.

To diagnose diffuse changes in the structure of the parenchyma of the organ can only be a qualified specialist with knowledge in physiology and anatomy, as it is a complex and time-consuming process. Thanks to modern advances in the field of ultrasound, the possibility of differential studies greatly expanded. But sometimes one diagnosis is not enough, asthe pathological condition can be quite serious, and morphological changes are not too bright.


The nature of the diffuse changes of parenchyma of the organ and the causes of this condition

Depending on the causes of diffuse changes of a liver, it may be of the following nature:

  • Fibrous change of the parenchyma. This occurs when due to certain pathological processes in the body begin to grow scar or so-called fibrous tissue. Its appearance can be triggered by a number of diseases, such as alcoholic, toxic, or viral hepatitis, because of congenital disease due to parasitic infection. Fibrotic changes can also be the result of any disease of another organ has a direct effect on the liver.
  • Hypertrophic nature of changes in the parenchyma.
  • Sclerotic changes in the parenchyma.
  • Swelling.

That is due to a number of reasons, changes of the parenchyma of the organ, and for clarification it is necessary to conduct additional tests. The stronger the inflammation, the noticeable swelling of the parenchyma.

Quite often, such a verdict can be heard in diseases of the following:

  • Diabetes, alcoholism and obesity. The liver is in such situations begins to degenerate, increase in size, the study echogenicity of its structure is several times higher than it should be OK.

  • In chronic hepatitis the liver can be greatly increased in size, but diffuse changes are not too bright.

  • If a person has cirrhosis, the structure of the body completely exposed to diffuse changes and becomes uneven, damaged many sites, echogenicity largely increased.

  • If the body had grown a cyst or a tumor, a lobe of the liver will see significant changes.

  • During viral infection, the liver parenchyma is modified, but these processes are not global in nature and on over time alone recovering.
  • Parasites can also cause of the fact that the liver parenchyma is diffuse changes.
  • Unsustainable approach to food, eating, calorie-dense fatty foods, and alcohol abuse has a negative impact on the structure of an organ and causes substantial changes in the parenchyma.

As becomes clear, the causes of radical changes in the structure of the body can be many. In order to clarify the diagnosis should conduct additional examination. They include the taking of blood for analysis: biochemical and clinical, serology, as well as a possible fence puncture of the liver, MRI, angiography, radioisotope scanning.


Treatment of diffuse changes of the liver parenchyma

If you consider that how such a diagnosis changes of the liver parenchyma does not exist, treatment methods are aimed at eliminating the disease that caused this transformation. Once the cause is identified, the doctor – hepatologist will determine the therapeutic regimen and prescribe the appropriate drugs.

Typically, the standard methods of treatment include administration of drugs in a specific pattern:

  • If the changes were caused by the viruses, it will be assigned to the antiviral agents designed to reduce their toxic impact on the body. Etiotroponogo treatment for hepatitis comes to the appointment of certain drugs, depending on its type. And also requires the elimination of additional damaging factors such as alcohol and other toxins. Often prescribed hepaprotective able to protect the hepatocytes. It may be the drugs of natural origin and synthetic, this includes amino acids, vitamins and phospholipids.

  • Phospholipids are able to normalize the membrane structure of liver cells, reduce necrosis of hepatocytes, resulting in biochemical parameters significantly improved.

  • Natural medicines have a stimulating effect on liver cells, making the hepatocytes restored, this effect is achieved also due to the choleretic effects of drugs. Improves the digestion process, the impact of harmful substances entering the body with alcohol, drugs and food to a significant degree is minimized.
  • The effect of synthetic drugs is varied and extremely difficult, as a rule, they are prescribed for cancer.
  • Amino acids help normalize the liver and fill the shortage of necessary compounds.
  • Vitamins b and E are hepaprotective and often prescribed in the overall scheme of liver.

In addition to compliance with treatment regimens in virtually any liver disease that caused her diffuse changes that require following a certain diet. Food will need to be adjusted in a special way how to do it correctly tell the doctor, but the main recommendations are as follows: elimination of salt, spices, spicy, fatty, fried foods. The introduction in the diet of fiber and foods rich in potassium. Of course, from the nature of the disease, the recommendations will vary in favor of certain products. But alcohol in the treatment of liver strictly contraindicated, as they in some cases can not only reduce the effectiveness of prescribed schemes, but in combination with certain medications can lead to death.

If changes parenchymal caused only by poor diet and the consumption of alcohol, doctors recommend a diet table number 5 on Pevsner classification, dominated by a fortified and protein foods, and dairy products. Depending on the condition of the body, with diffuse changes of the liver parenchyma, also prescribed immunomodulators and some liver fees.

On topic: the list of the best hepatoprotectors to restore the liver

The prognosis of diffuse changes of the liver parenchyma

Of course, that forecast the success of the application of a particular treatment regimen depends on disease, which resulted in diffuse disorders of the parenchyma of the liver.

If we consider the uncomplicated form of lipomatosis, the majority of chronic hepatitis, as well as changes of the parenchyma due to poor diet and lifestyle, proper treatment in most cases leads to the fact that the body begins to function in the same volume, and it disrupted the structure is restored. You should consider that when lipomatosis favorable outcome of treatment directly will depend on what area of the liver was exposed to fatty degeneration. As in this case, the recovery of the affected areas impossible. Will only be to normalize the functioning of the unaffected lobes of the organ.

Poor prognosis differ diseases such as cirrhosis, fulminant forms of hepatitis, as well as uncontrolled steatosis. In these cases, the parenchyma of the liver changed dramatically, andthe body becomes unable to perform its functions. Death most often occurs because of intra-abdominal bleeding or the development of severe infectious diseases.

It should be understood that changes of the liver parenchyma diffuse nature, cannot be baseless. Such disruption of the structure body is always preceded by a number of reasons. Depending on those factors or diseases that triggered a diffuse transformation of the liver parenchyma, gepatologii is assigned to the appropriate treatment. But for the moment was not lost by you, you must at least once a year to undergo ultrasound from qualified professionals. The sooner will be revealed diffuse changes of a parenchyma of a liver, the more favourable the prognosis for a full recovery.


orshenin Elena Ivanovna, doctor-gastroenterologist